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Scientific Updates /

Meta-analysis confirms soya protein's cholesterol - lowering effect

23 May 2019


Original research

The most recent meta-analysis to date has confirmed that a daily consumption of 25g soya protein could result in a modest but significant reduction in total and low-density lipoprotein (LDL) cholesterol – beyond the effect seen from the displacement of saturated fat intake.

Study overview

The authors undertook the analysis on 46 randomised-controlled studies selected by the American health claims authority (Food and Drug Administration – FDA) for their review of the currently approved soya health claim.

The analysis included a total of 2,607 men and women with a mean baseline total and LDL-cholesterol of 226.3mg/dL (5.85mmol/L) and 147.6mg/dL (3.82mmol/L) respectively.

Key findings

Over a median 6-week period, consumption of 25g soya protein daily significantly reduced:

  • LDL-cholesterol by -3.2% (ranging from -1.9% to -4.5%):

    • -4.76mg/dL (range -2.8 to -6.71) [-0.12mmol/L (-0.07 to -0.17)]

  • Total cholesterol by -2.8% (ranging from -1.5% to -4.1%):

    • -6.41mg/dL (range -3.52 to -9.3) [-0.17mmol/L (-0.09 to -0.24)]

The study also confirmed this effect to be intrinsic and further reductions could be gained if the soya food consumed displaced higher saturated fat foods in the diet. The study did not identify a dose-dependent response, and the authors noted that eight of the studies used less than 25g soya protein which, could indicate that quantities below 25g soya protein could be as effective.

25g soya protein equates to: 2 large (250ml) glasses of soya drink, 100g soya mince or 100g tofu


Inclusion of soya foods and drinks is in line with current heart health organisations’ dietary recommendations for cholesterol-lowering, which encourage increased consumption of lower saturated fat plant-based protein foods in place of higher saturated fat animal proteins.

This study concurs with previous meta-analysis, that soya protein reduces cholesterol levels beyond the effect of displacing saturated fat in the diet: an additional 2.8% reduction in total and 3.2% LDL-cholesterol.


  1. Mejia SB, Messina M, Li SS, et al . Meta-analysis of 46 studies identified by the FDA demonstrates that soy protein decreases circulating LDL and total cholesterol concentrations in adults. J Nutr. 2019:149(6);968–981.

Alpro Foundation report

Plant-based eating and cardiometabolic health

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